EXTINCTION OF EXPERIMENTAL MAMMARY CANCER, I. ESTRADIOL-17 AND PROGESTERONE
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چکیده
منابع مشابه
Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.
OBJECTIVE The goal of this pilot study was to evaluate the effects of testosterone (T) cotherapy on mammary gland and endometrial measures in a postmenopausal primate model. METHODS Twenty-five surgically postmenopausal cynomolgus monkeys were randomized by social group to receive daily treatment with (1) placebo, (2) oral micronized 17beta-estradiol (1 mg/d equivalent in women) + progesteron...
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The clinical observation that coronary artery disease is more common in men and postmenopausal women than in premenopausal women has suggested cardioprotective effects of female sex hormones including hormone-mediated coronary vasodilation. The purpose of this study was to investigate whether the sex hormone-induced coronary relaxation is caused by inhibition of Ca2+ mobilization into coronary ...
متن کاملProgesterone and progesterone receptors in experimental breast cancer.
in ER-positive tumors would indicate that the tumor is capa ble of synthesizing at least 1 end product under estrogen regulation and may therefore be endocrine responsive (8). Although the hypothesis assumes that PGR levels in breast tumors, like those in the uterus, are under estrogen control, this priming effect has never been demonstrated. In this paper we show that PGR in the DMBA-induced m...
متن کاملEstradiol, Progesterone and Cytokines Production
OBJECTIVES: The purpose of this study was to determine the effects of estradiol and progesterone on interferon-γ (IFN-γ), interleukin (IL)-12, IL-10 and tumor necrosis factor-α (TNF-α) productions in polyclonal activators (phyto hemagglutinin+lipopolysaccharide)-stimulated whole blood cultures. METHODS : Nineteen healthy males and females volunteered in the study. Blood samples were drawn, dilu...
متن کاملEffects of ionizing irradiation on the estradiol and progesterone receptors in rat mammary tumors.
The determination of estradiol and progesterone receptor concentrations in mammary tumors is useful in predicting the hormone responsiveness. As this assay is carried out on tumor tissue which may have been subjected to radiotherapy, the possibility of an ionizing irradiation affecting the steroid receptor levels in neoplastic tissue should be taken into account. The steroid receptor concentrat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1962
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.48.3.379